Hematopoietic stem cell transplantation (HSCT)
HSCT, commonly known as bone marrow transplant, involves injecting healthy stem cells back into the patient’s body after diseased stem cells have been destroyed during the pre-transplant conditioning regimen (chemotherapy-based). Conditioning is a very important moment, because you have to make sure that the child is well prepared for the transplant, so that his body does not reject it (side effect). In addition to the translational research projects on HSCT already mentioned, certain clinical research projects on HSCT are also carried out in collaboration with the Pediatric Oncology and Hematology Unit of the HUG. As clinical research, the platform has an ongoing study under the direction of Dr F. Bernard on HSCT in non-malignant diseases, in collaboration with the UK Pediatric BMT Group for HSCT in Fanconi’s anemias. Similarly, two other studies are underway for the management of patients who must receive HSCT in general: a first with the Pediatric Disease Working Party of the EBMT on a predictive score of the results of HSCT in pediatrics and a second in collaboration with French and English centers on the education of transplanted children.
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