Article in the “Journal of Clinical Oncology” of 1 February 2021 on the interim results of the FORUM study
A publication in the prestigious Journal of Clinical Oncology (read article), prepared in collaboration with CANSEARCH-supported researchers, reveals the interim results of the FORUM study. The aim of the study was to investigate whether chemotherapy prior to bone marrow or haematopoietic stem cell transplantation for acute lymphoblastic leukaemia in children was preferable to the commonly used radiation therapy, which has many side effects. However, the study finally showed that, despite the good results obtained with chemotherapy, those of radiotherapy remain better in terms of cure rates. Based on this finding, the CANSEARCH research platform is continuing this study by analysing other factors, such as the pharmacokinetics of Busulfan linked to the genetics of the young patient. To date, the DNA of more than 300 patients has been sequenced to obtain results on these aspects in particular.